Extra-skeletal effects of bisphosphonates
WebApr 25, 2013 · Side effects of bisphosphonates mainly include acute phase reactions, hypocalcemia, hypophosphatemia, gastrointestinal events after oral administration, and inflammatory reactions at the injection site. 4-9 Osteonecrosis of the jaw (ONJ) is an important but rare complication of bisphosphonates, more often observed with … WebAbstract. Purpose of review: Recent evidence from clinical trials and observational studies raises the possibility that bisphosphonate use might confer a lower risk of cardiovascular disease and cancer, resulting in a mortality benefit. This review summarizes clinical and preclinical studies examining the non-skeletal effects of bisphosphonates.
Extra-skeletal effects of bisphosphonates
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WebThe uses of bisphosphonates include the prevention and treatment of osteoporosis, Paget's disease of bone, bone metastasis (with or without hypercalcemia ), multiple myeloma, primary hyperparathyroidism, osteogenesis imperfecta, fibrous dysplasia, and other conditions that exhibit bone fragility. Medical uses [ edit] WebDec 11, 2013 · Bone fragility, leading to fractures and disability, is implicated in the pathogenesis of various bone-desorption diseases induced by glucocorticoid excess, sex …
WebDec 4, 2006 · Search worldwide, life-sciences literature Search. Advanced Search Coronavirus articles and preprints Search examples: "breast cancer" Smith J WebBisphosphonates are considered the most effective drugs for controlling adult and pediatric osteolytic diseases. Although they have been used successfully for many years, several …
WebMay 1, 2024 · The extraskeletal effects of bisphosphonates on inhibition of tumor growth are known. However, our knowledge of the effects of bisphosphonates on muscle … WebSep 12, 2011 · The effects of BPs include the reduction of bone loss and of the risk of pathological fractures; these drugs are thus administered to patients suffering from destructive bone lesions resulting...
WebJan 13, 2024 · Nitrogen-containing bisphosphonates (NCBP) demonstrated pharmacological effects similar to statins. NCBP increased serum high-density lipoprotein cholesterol, decreased levels of low-density lipoprotein cholesterol, and inhibited the secretion of inflammatory cytokines [ 35, 36, 37 ].
WebNational Center for Biotechnology Information crbn locationWebSep 1, 2024 · Bisphosphonates have been a standard treatment for bone metastases, osteoporosis, and cancer treatment–induced bone diseases. The extraskeletal effects of … crbn in telecomWebJul 9, 2015 · Since the approval of etidronate for hypercalcemia of malignancy in the late 1980s, bisphosphonates have become the standard of care in the treatment of cancer-associated hypercalcemia providing safe, effective, and sustained reductions in serum calcium levels. 2 Pyrophosphate analogs, bisphosphonates, inhibit osteoclast activity in … dlsud senior high school calendarWebDec 11, 2013 · Extra-skeletal Previous studies of radio-labeled compounds showed that BPs are taken up and adsorbed in to bone primarily, but some also goes to soft tissues, such as the liver, kidney, and spleen [12,13]. The distribution of BPs in extra-skeletal tissue differs, with potential differences in plasma protein binding and kidney concentrations. crbn meaningWebBone metastatic disease is a late-stage event of many common cancers, such as those of prostate and breast. It is incurable and causes severe morbidity. Tumor and bone interact in a vicious cycle, where tumor-secreted factors stimulate bone cells, which in turn release growth factors and cytokines that act back on the tumor cells. dlsu ethics formWebApr 11, 2024 · On the contrary, numerous extra-telomeric functions are likely responsible and link telomere biology to other hallmarks of ageing (Lopez-Otin et al., 2013). Therefore, future work should seek to elucidate whether the extra-telomeric functions presented in this review are involved in physiological adaptations to endurance training. crbn ikzf1WebBisphosphonates are long-acting. 1 Metaphyseal sclerotic “banding” is a well-recognized effect of periodic intravenous bisphosphonate treatment in growing children, 2,5,22 yet epiphyseal and ... dlsu flow chart