Crbn location
WebCRBN (MRT2, MRT2A) protein expression summary. This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product i s found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal … WebDec 1, 2001 · Function. Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal …
Crbn location
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WebSep 16, 2024 · Currently, IMiDs are the backbone of MM therapy in newly diagnosed and relapsed/refractory settings. It is now known that IMiDs exert their anti-myeloma activity mainly by binding cereblon (CRBN), the substrate receptor protein of the CRL4 E3 ubiquitin ligase (CRL4 CRBN) complex. By binding CRBN, IMiDs alter its substrate specificity, … WebNM_016302.4(CRBN):c.16G>C (p.Asp6His) AND not specified Clinical significance: Uncertain significance (Last evaluated: Jan 29, 2016) Review status: 1 star out of maximum of 4 stars
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WebMar 1, 2003 · Crbn. Status. UniProtKB reviewed (Swiss-Prot) Organism. Mus musculus (Mouse) Amino acids. 445. Protein existence. Evidence at protein level. Annotation score. 5/5. Entry. ... Subcellular Location. UniProt Annotation. GO Annotation. Cytoplasm By similarity. Nucleus By similarity. Membrane By similarity
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