Web11 apr. 2024 · Increasing synaptic activity in primary hippocampal cultures mediates the post-translational modification of the palmitoylating enzymes ZDHHC2, ... Cells were nucleofected with myc–PLK2 -WT or kinase-dead PLK2 (myc–PLK2-K108M) ... Several cysteine residues in the C-terminal region of ZDHHC5 are known to be palmitoylated ...

Biomedicines Free Full-Text An Electrophilic Deguelin Analogue ...

WebOncogenic MYC profoundly alters metabolism and mediates an antioxidant response to maintain redox balance. Here we show that MYCN induces massive lipid peroxidation on depletion of cysteine, the rate-limiting amino acid for glutathione (GSH) biosynthesis, and sensitizes cells to ferroptosis, an oxidative, non-apoptotic and iron-dependent type of cell … Web3 mei 2024 · 这项发现要从一种近期备受关注的癌基因家族成员——mycn基因说起。最近有研究指出，作为疾病发展方向的调控因素，mycn基因决定了前体细胞是否 ... hortonworks inc stock price

Activity-dependent post-translational regulation of palmitoylating …

WebHowever, the fundamental issue of how MYC mediates its diverse and critical biological roles at the molecular level has not been fully resolved (Meyer and Penn ... (Seo et al. 2008) and a MYC S62A mutated protein, unlike MYC, fails to be recruited to the γ-glutamyl cysteine synthetase promoter (Benassi et al. 2006). WebMurine caspase-11 (caspase-4 and caspase-5 in humans) mediates noncanonical inflammasome signaling, leading to pyroptotic cell death in response to Gram-negative bacteria infection (Kayagaki et al., 2011; Broz et al., 2012; Rathinam et al., 2012; Aachoui et al., 2013).Cytoplasmic LPS derived from invading Gram-negative bacteria is the … WebA network of protein–protein interactions (PPI) is involved in the activation of (+)-7-iso-jasmonoyl-L-isoleucine (JA-Ile), a plant hormone that regulates plant defense responses as well as plant growth and development. In the absence of JA-Ile, inhibitory protein jasmonate-ZIM-domain (JAZ) represses JA-related transcription factors, including a master … hortonworks lunch