Web14 jan. 2024 · This section describes how to label amyloid plaques with methoxy-X04 (MeX04), a blood–brain barrier-penetrating amyloid-beta (Aβ) dye. After MeX04 is … WebThe methoxy-X04-derivative BSC4090 is a fluorescent ligand which was designed to target neurofibrillary tangles in AD. ... Using NMR spectroscopy, we find that BSC4090 binds …
Evaluation of the methoxy-X04 derivative BSC4090 for diagnosis of ...
WebSubmitted. Rob J.A. Nabuurs. 1. Varsha V. Kapoerchan. 2. Athanasios Metaxas. 3. Sarah Hafith. 1. Maaike de Backer. 1. Mick M. Welling. 1. Wim Jiskoot. 4. Adrianus M.C ... WebGuidechem provides Methoxy-X04 chemical database query, including CAS registy number 863918-78-9, Methoxy-X04 MSDS (Material Safety Data Sheet), nature, English name, … port clogged symptoms
Evaluation of the methoxy-X04 derivative BSC4090 for diagnosis …
WebMethoxy-X04 is a brain-permeable fluorescent probe for amyloid-β (Aβ) to detect and quantify plaques, tangles, and cerebrovascular amyloid.1 It displays high in vitro binding affinity (Ki = 26.8 nM) for fibrillar β-sheet deposits and is used to image Aβ plaques in the brains of living APP/PS1 mice, a transgenic model of familial Alzheimer's disease.[1],[2] … WebName: Methoxy-X04 CAS#: 863918-78-9 Chemical Formula: C23H20O3 Exact Mass: 344.1412 Molecular Weight: 344.41 Elemental Analysis: C, 80.21; H, 5.85; O, 13.94 Price and Availability Technical data Biological activity Solubility and formulation Protocols Calculators References Synonym: Methoxy-X04 WebBack to Top Abstract Methoxy compounds, including methyl carboxylic esters, exhibit a weak band in the 2860–2800 cm−1 region of the infrared spectrum, which is diagnostic for the methoxyl group. The band occurs at a lower frequency than that of the main C–H absorption. port closed windows 10