Fgfr2-bicc1
WebJan 22, 2015 · FGFR2–PPHLN1 and the previously reported FGFR2–BICC1 were present in 16% and 38% of iCCA cases, respectively, and were not mutually exclusive. Presence of FGFR2 rearrangements was also... WebDec 3, 2024 · We also observed nine novel FGFR2 SNVs (in addition to others that have been previously reported) in a patient with an FGFR2–BICC1 fusion treated with infigratinib: D651Y, E566G, L551/2F, L551F ...
Fgfr2-bicc1
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WebJul 16, 2024 · A biopsy from a lung mass revealed a moderately differentiated adenocarcinoma. Immunohistochemistry (IHC) staining was positive for CK-7 and negative for CK-20, consistent with a lung primary. The programmed death-ligand 1 score was < 1%. The tu-mor harbored an FGFR2-BICC1 fusion in 10.5% of cell-free DNA. The patient …
WebJul 28, 2024 · Fifty-six patients (92%) had the exact alteration identified. The most common FGFR genetic alteration seen in our study was the FGFR2-BICC1 fusion (n = 11, 18%). Fifty (82%) patients had an FGFR2 fusion or rearrangement and 11 (18%) patients had other FGFR alterations. WebApr 14, 2024 · 疗效人群包括一组 1 名患者，他们入组本研究的疾病在至少一次先前化疗时或之后进展，并且至少有以下遗传改变之一：fgfr3 基因突变（r248c、s249c、g370c …
WebBICC1-FGFR2 Fusion is present in 0.02% of AACR GENIE cases, with intrahepatic cholangiocarcinoma, adenocarcinoma of unknown primary, cancer of unknown primary, … WebFeb 2, 2024 · Although the most prevalent FGFR2 partner (BICC1) has a dimerization domain, not all FGFR2 rearrangement partners have known or predicted dimerization domains, suggesting that the pervasiveness of FGFR2 partners may be due to lack of requirement for sequence or functional specificity of partner genes.
WebCD51 + CD61 (Integrin alpha V + Integrin beta 3) CD51 / Integrin alpha V. CD52
WebNov 3, 2024 · In FGFR2 transfected Ba/F3 cell lines, derazantinib displayed potent inhibition of FGFR2 fusions, including FGFR2-CCDC6, FGFR2-BICC1, TEL-FGFR2, FGFR3-BAIAP2L1 and FGFR2-AAF3 with GI 50 values between 39.9 nM and 1121 nM. Derazantinib also showed strong tumor inhibition in FGFR2 fusion-driven tumor … navigation bar on the left outlookWebNational Center for Biotechnology Information navigation bar on left side outlookWebThe gene view histogram is a graphical view of mutations across FGFR2. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left. navigation bar on wordWebApr 1, 2024 · FGFR2-BICC1 (Table 1, Fig. 5) was first discovered in patients with the translocation t(10;10)(q21;q26), joining exon 19 of FGFR2 and exon 3 of BICC3. Since … navigation bar on computerWebApr 3, 2024 · Eighty-six percent of patients had in-frame FGFR2 gene fusions and the most commonly identified FGFR2 fusion was FGFR2-BICC1 (34%). Fourteen percent of patients had other FGFR2 rearrangements that could not be confidently predicted to be in-frame fusions, including rearrangements without an identifiable partner gene. ... navigation bar popup windowWebIn the present work, we present a case of cholangiocarcinoma who had FGFR2-BICC1 rearrangement detected by NGS. A 76-year-old female diagnosed with … navigation bar on tabletWebMay 25, 2024 · FGFR3-TACC3 was the most prevalent FGFR rearrangement (29.0%), followed by FGFR2-BICC1 and FGFR2-N/A (both 9.7%). In vitro analysis of the transforming potential and drug sensitivity for select alterations will be reported. marketplace jefferson city missouri